ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering. Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
The role of kidney injury biomarkers in COVID-19COVID-19에서 신장 손상 바이오마커의 역할Review Published on 2022-12-012022-09-11 Journal: Renal failure [Category] 바이오마커, [키워드] Acute kidney injury AKI Biomarker biomarker. Biomarkers clinical settings complex coronavirus coronavirus disease COVID-19 death demonstrated Diagnosis disease Disease progression early diagnosis global pandemic high mortality rate hospital IGFBP7 IL-18 IMPROVE independent risk factor Intervention kidney Kidney injury molecular molecular mechanism molecular mechanisms outbreak outcomes Patient patients with COVID-19 Research Sepsis suPAR unique [DOI] 10.1080/0886022X.2022.2107544 PMC 바로가기 [Article Type] Review
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
A hybrid random forest deep learning classifier empowered edge cloud architecture for COVID-19 and pneumonia detectionResearch article Published on 2022-12-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy Affect Algorithm Classifier cloud computing complex computation conducted COVID-19 COVID19 CT scan dataset datasets deep deep learning detect diagnose effective Efficiency evaluate False positives forest global pandemic Healthcare industry heat Heat Transfer Search algorithm identify immunization inefficient Interaction less lung CT scan methodology offer outcomes overcome Patient Pneumonia predict PROTECT random Random forest resource Support the patient virus Web services X-ray [DOI] 10.1016/j.eswa.2022.118227 [Article Type] Research article
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cellsArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals approved drug caused clinical evaluation Combination Compound concentrations conducted COVID-19 drug Effect Efficacy epithelial cell line exonuclease global pandemic HCV hepatitis C human lung human lung cell identify inhibitor moderate morbidity Mortality NS5A pharmacokinetic profiles Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication Support synergy the SARS-CoV-2 therapeutic treatment strategy virus [DOI] 10.1038/s41598-022-21034-5 PMC 바로가기
Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interactionArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting-enzyme-2 binding binding interaction blocking virus entry Brown caused characterized coronavirus demonstrated disease ELISA enzyme-linked immunosorbent evaluate evaluated feasible global pandemic immunization immunized Immunoglobulin immunoglobulin Y in vitro Infection inhibit kDa Laying Laying hens molecular weight Neutralizing nucleocapsid purified RBD RBD-ACE2 Receptor binding domain Receptor-binding-domain SARS-CoV-2 SARS-CoV-2. SDS-PAGE serum Specific spike glycoprotein [DOI] 10.1016/j.intimp.2022.109280 PMC 바로가기
A precise review on NAATs-based diagnostic assays for COVID-19: A motion in fast POC molecular testsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Investigation [Category] SARS, 치료기술, [키워드] addressed advance approved assist authorization Care Comparative coronavirus disease COVID-19 diagnostic Diagnostic method disease Emergency expand false-negative global pandemic Health limitation mitigate molecular molecular diagnostic assays molecular test NAAT New nucleic acid amplification nucleic acid amplification techniques parameter platform POC POC testing point-of-care Point-of-care testing. polymerase chain RT-qPCR SARS-CoV-2 Sensitivity and specificity suggested [DOI] 10.1111/eci.13853 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Cov-Net: A computer-aided diagnosis method for recognizing COVID-19 from chest X-ray images via machine visionResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy Algorithms applied asymmetric backbone build CAD Chest X-ray image Computer aided diagnosis (CAD) conditions Convolution Coronavirus disease 2019 COVID-19 database demonstrated Diagnosis Experimental result feature Feature learning global pandemic Image recognition information machine vision mechanism methodology outperform Perspective practicality recognizing robust selected Symptomatic patients [DOI] 10.1016/j.eswa.2022.118029 [Article Type] Research article
The New SARS-CoV-2 Variants and Their Epidemiological Impact in MexicoArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome caused coronavirus COVID-19 COVID-19 disease COVID-19 pandemic Epidemiology evaluate example genomic genomic vigilance global pandemic help Heterologous Immunity Impact impacted Latin America mitigate New pandemic prevalent SARS-CoV-2 SARS-CoV-2 variants Surveillance the disease vaccination vaccination. variant variants virus Wuhan, China [DOI] 10.1128/mbio.01060-21 PMC 바로가기